https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30816 80% activity vs. baseline. A significant, reversible, time-dependent inhibition was observed with lansoprazole (66% activity at 240 min, P = 0.034) and rabeprazole (25% activity at 240 min, P < 0.001). In regression analysis, PPI use was not associated with ADMA in HCS participants (beta 0.012, 95% CI −0.001 to 0.025, P = 0.077). Furthermore, there were no differences in ADMA between specific PPIs (P = 0.748). At clinical concentrations, PPIs are weak, reversible, DDAH1 inhibitors in vitro. The lack of significant associations between PPIs and ADMA in HCS participants questions the significance of DDAH1 inhibition as a mechanism explaining the increased cardiovascular risk reported with PPI use.]]> Wed 11 Apr 2018 12:32:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19975 Sat 24 Mar 2018 07:54:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24504 Sat 24 Mar 2018 07:13:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32138 Mon 23 Sep 2019 13:50:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30117 Fri 01 May 2020 07:02:02 AEST ]]>